Treatment Resistant Depression

There’s Hope for Treatment Resistant Depression

Approximately half of those diagnosed with clinical depression will be labeled as non-responders during some point of their care. Non-responsive depression is depression that does not get better when treated with standard antidepressant medication and/or talk therapy. This form of the disorder is also known as treatment resistant depression, or TRD for short. Individuals with TRD struggle for years, sometimes decades with uncontrollable depressive symptoms. Often these symptoms of depression increase in severity over time when not properly treated. For those with TRD, their situation can seem hopeless.

Recent breakthroughs in depression treatment have made it possible to treat severe, chronic depression on an outpatient basis, without the need for hospitalization. At the Delray Center for Integrative Medicine, founder and medical director Raul J. Rodriguez, MD and his team have been successfully treating the worst cases of treatment resistant depression for years. At DCIM, Dr. Rodriguez and his multidisciplinary team of psychiatrists and psychotherapists offer a holistic and integrative model for the treatment of depression, anxiety, and other mood disorders. Our approach takes into account each patient’s specific neurochemistry, psychological symptoms, and physiology, and utilizes only the most cutting-edge mental health treatment methods.

Ketamine Infusions for Depression

Ketamine, originally developed for the use as anesthetic, has been found to alleviate even the worst depressive features in a short amount of time, when prescribed off-label and administered in lower doses using specific protocols. Ketamine is being hailed by some as a wonder drug for those who conventional antidepressants and therapy have failed. Ketamine treatment for depression is administered in a IV infusions using a micro-dose of the medication, while under the care of a trained medical professional. The powerful antidepressant effect of Ketamine occurs in a matter of minutes, and can last for weeks from a single infusions even though the medication leaves the body in a few hours.

Ketamine works by acting upon certain proteins in the brain, that work like molecular switches affecting neural activity. Individuals with depression have an over-abundance of specific G proteins, that build up and block signaling between brain cells. Ketamine forces out accumulated G proteins, returning brain cell activity to normal. This happens in a matter of minutes with therapeutic IV ketamine infusions, as opposed to months with traditional SSRIs & antidepressants. The dramatic effect Ketamine has makes it a viable option for depressed individuals that other medications did not work for.

Contact us today for help: 561-220-5299

Dr. Raul J. Rodriguez

Dr. Raul Rodriguez


  • “Dr. Rodriguez has created a place that is truly focused on healing. There are so many types of treatment options and they are focused on finding the one that is right for you.”

    - BA, Delray Beach

  • “This center is a very special place. Everyone is warm, caring, supportive, and professional. It helped me overcome my anxiety and depression. I love the emphasis on mindfulness, yoga and exercise as well as traditional therapy”

    - SG, Boca Raton

Existing patients, please text 561-409-7296 for follow-up appointment requests or if you have medication concerns please text 561-409-7296.